GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs2241437 | 1 | rs12620810 | chr2:86391481 | LOC90784 | chr2:86247339-86250991:- | -0.27 | -3.49 | 0.0005 | Response to methylphenidate treatment in attention-deficit/hyperactivity disorder (blood pressure) |
| BRCA | cis | rs2241437 | 1 | rs12620810 | chr2:86391481 | ST3GAL5 | chr2:86066271-86116157:- | 0.32 | 4.49 | 7.79E-6 | Response to methylphenidate treatment in attention-deficit/hyperactivity disorder (blood pressure) |
| BRCA | cis | rs9677476 | 1 | rs12621280 | chr2:232132984 | ARMC9 | chr2:232063342-232238606:+ | 0.17 | 4.98 | 7.48E-7 | Food antigen IgG levels |
| BRCA | cis | rs9677476 | 1 | rs12621280 | chr2:232132984 | HTR2B | chr2:231972952-231989824:- | 0.18 | 5.95 | 3.69E-9 | Food antigen IgG levels |
| BRCA | cis | rs986417 | 1 | rs1262174 | chr14:60887194 | DHRS7 | chr14:60611502-60636561:- | 0.18 | 3.5 | 0.000481 | Gut microbiota (bacterial taxa) |
| BRCA | cis | rs12618769 | 1 | rs12623494 | chr2:99245917 | UNC50 | chr2:99225042-99234975:+ | -0.2 | -4.16 | 3.48E-5 | Bipolar disorder |
| BRCA | cis | rs802075 | 1 | rs12624 | chr6:49660418 | CRISP3 | chr6:49695092-49712056:- | 0.14 | 3.69 | 0.000238 | Bone mineral density (hip) and age at menarche |
| BRCA | cis | rs6771316 | 1 | rs12631016 | chr3:72130202 | GXYLT2 | chr3:72937385-73024520:+ | 0.1 | 3.39 | 0.000734 | Venous thromboembolism (SNP x SNP interaction) |
| BRCA | cis | rs4679904 | 1 | rs12632274 | chr3:160343281 | TRIM59 | chr3:160153292-160167626:- | 0.13 | 3.98 | 7.49E-5 | Primary biliary cirrhosis |
| BRCA | cis | rs4678181 | 1 | rs12632654 | chr3:122053941 | LOC100129550 | chr3:122605360-122611262:+ | -0.24 | -4.42 | 1.11E-5 | Calcium levels |
| BRCA | cis | rs10935120 | 1 | rs12637751 | chr3:134266124 | ANAPC13 | chr3:134196547-134204865:- | -0.41 | -13.19 | 6.77E-37 | Height |
| BRCA | cis | rs10935120 | 1 | rs12637751 | chr3:134266124 | CEP63 | chr3:134204575-134293852:+ | -0.14 | -3.72 | 0.000212 | Height |
| BRCA | cis | rs12638253 | 1 | rs12638253 | chr3:156626091 | LEKR1 | chr3:156544076-156763918:+ | -0.18 | -4.83 | 1.59E-6 | Multiple sclerosis (severity) |
| BRCA | cis | rs11097912 | 1 | rs12642900 | chr4:107010329 | TBCK | chr4:106967233-107237861:- | 0.23 | 7.14 | 1.74E-12 | Airflow obstruction |
| BRCA | cis | rs7665090 | 1 | rs12644381 | chr4:103552430 | MANBA | chr4:103552644-103682151:- | 0.21 | 5.39 | 8.62E-8 | Primary biliary cirrhosis |